In response to our customers' desire for more complete neuronutrition at an affordable price, we proudly introduce NeuroTone! Each of the eleven nutritional substances in NeuroTone is provided in meaningful amounts and is supported by relevant scientific or clinical studies. The combined action of key neurotransmitter precursors and protective antioxidant substances in the formula make NeuroTone a useful dietary adjunct for enhancing brain and nervous system functions involved in maintaining mental alertness, clarity, and memory retention.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, cure or prevent disease.

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Four Tablets Contain:

Acetyl-L-Carnitine (100% pure hydrochloride form) 500mg

Phosphatidylserine (from soy lecithin) 50mg

Ginkgo Biloba (min. 27% ginkgo flavone glycosides, min. 7% terpene lactones) 80mg

DMAE (dimethylaminoethanol) 100mg

Choline Bitartrate 150mg

L-Glutamine 500mg

L-Pyroglutamine acid 250mg

L-Tyrosine 250mg

Siberian Ginseng (min. 0.8% ginsenosides) 150mg

Ashwagandha Extract (min. 1.5% withanolides, min. 1% alkaloids) 150mg

*Neuromins TM DHA Powder 300mg

Supplying:

• Docosohexaenoic acid 42mg
• Lecithin 250mg

Supplying approximately:

• Phosphatidylcholine 65mg
• Phosphatidylethanolamine 50mg
• Phosphatidylinositol 35mg

*Neuromins is a trademark of Martek Biosciences Corporation; U.S. Patent #'s 5,407,957 and 5,492,938.

Suggested Usage:

Adults take 2 tablets twice daily or as directed by physician. Children take 1 tablet twice daily or as directed by physician.

NeuroTone:   An advanced brain nutrient supplement to enhance cognitive function

Age-associated memory impairment is of increasing interest and concern as the baby-boomer generation enters their forties and fifties. Losing one's ability to think clearly and retain mental sharpness is a common fear for all of us. As an active area of research, numerous nutrients have been recently reported to enhance memory function and provide protection for the aging brain. Compounds such as Acetyl-L-Carnitine, Phosphatidylserine, Docosahexaenoic acid, Ginkgo biloba, DMAE, and others have valuable roles in neuronutrition. Yet, the more we learn about the benefits of these nutrients, the more confusing it becomes deciding on which one(s) to take. Supplementing with only one or a few of these important substances may not provide the full advantages of a mixed and balanced array of needed nutrients. And ingesting them all as separate supplements is not only cumbersome, but quite costly.

Supports synthesis of key neurotransmitters.

Effective communication is as important between brain and nerve cells as it is in our daily relationships. Cellular communication forms the basis of maintaining healthy mental capacities. A complicated network of neurotransmitters, peptides, and other substances is responsible for brain functions involving mood regulation, memory retention, and behavior. Receptors on each nerve cell receive specific signals carried by chemical neurotransmitter substances. When a neurotransmitter binds to a receptor, a series of molecular events responsible for key brain functions is set in motion. Select nutrients in NeuroTone support neurotransmitter metabolism in the following ways:

Acetyl-L-Carnitine: This acetylated high energy ester of the amino acid L-carnitine contributes its acetyl groups to the production and release of acetylcholine, the primary neurotransmitter for memory and thought. The carnitine component plays a key role in the transport of fatty acids into the nerve cell mitochondria where they serve as fuel for cellular energy production.

L-Glutamine: The brain depends on various amino acids for its functions. The non-essential amino acid glutamine easily crosses the blood-brain barrier where it can be converted into two important neurotransmitters, the excitatory L-glutamic acid and the major inhibitory neurotransmitter gamma amino butyric acid (GABA).

Lecithin (Phosphatidylcholine) and Choline: Choline, related to the B vitamins, is the other critical precursor to acetylcholine synthesis. Choline is water soluble and therefore faster acting whereas phosphatidylcholine as a source of choline is fat soluble and has a longer-lasting, sustained effect on acetylcholine production.

DMAE (dimethylaminoethanol): DMAE aids the synthesis of acetylcholine by being able to pass through the blood brain barrier where it can then be converted to choline in the brain. Supplementation has been reported to benefit short-term memory and increase speed of learning.

L-Pyroglutamic acid: This amino acid compound boosts the metabolism of acetylcholine-releasing nerve cells thereby improving synthesis and release of this important memory and thought neurotransmitter.

L-Tyrosine: This important amino acid is a direct precursor for the catecholamines norepinephrine and dopamine. Norepinephrine is involved in long-term memory and has an energizing, mood-elevating action. Dopamine is the principal neurotransmitter involved in central nervous system control of muscle movement.

Enhances microcirculation to the brain.

The brain is one of the most metabolically active organs in the body. Its enormous rate of oxygen consumption - about one-fifth of the body's total - provides the energy required for its intense chemical activities. Continuous, unimpeded blood flow to the brain, day and night, is a necessity in order to satisfy the brain's demanding appetite for oxygen. Our circulatory system carries nutrients, including oxygen, to the tissues and removes metabolic by-products. Diminished blood flow to the brain can therefore have significant impact on the ability of the brain to function normally. When the brain does not get the glucose, oxygen, and other nutrients it needs to support energy metabolism, moderate to severe impairment of mental activities and behavioral functions can result.

NeuroTone includes two circulation-supporting substances to encourage healthy flow of oxygen and nutrients to brain tissues.

Ginkgo Biloba: This well-studied botanical compound has gained favorable notoriety for its positive effect on enhancing circulation to the brain and extremities. Specific flavonoid compounds and terpene lactones contained in the ginkgo leaf help regulate the tone and elasticity of both arteries and capillaries. Increasing circulation to the brain and other parts of the body allows for better oxygen and glucose uptake, with subsequent enhancement of memory and mental functions.

Acetyl-L-Carnitine: Human studies have shown another role of this amino acid compound is to increase cerebral blood flow.

Stabilizes and restores nerve cell membranes.

Nerve cells control their environment by pumping beneficial nutrients into the cell and transporting waste products out. Transport mechanisms within cell membranes are responsible for performing these critical functions. When damage to membranes occur, such as during aging or oxidative damage, these processes are impaired and neuronal dysfunctions result. Maintaining fluidity of cell membranes is crucial to preserving their optimum receptor, enzyme, and transport functions. NeuroTone helps stabilize and restore normal cell membrane activities with the following nutrients:

Lecithin: Lecithin is the principle source of phosphatidylcholine which is used to repair and maintain nerve cell membranes. Phosphatidylcholine is a major constituent in the synthesis of myelin, the insulating sheath around nerve cells that helps ensure effective transmission of nerve cell activity.

Acetyl-L-Carnitine: This helps to preserve and restore the stability and fluidity of nerve cell membranes, thereby opposing age-associated rigidity which leads to impairment in membrane activity and receptor function.

Phosphatidylserine: This phospholipid, found in high concentrations in the nervous system, helps maintain nerve membrane fluidity for the optimal passage of nutrients and other compounds within and through nerve cell membranes. It is also used in the repair and regeneration of nerve cells.

DHA (docosahexaenoic acid): As the most abundant fatty acid in the brain, DHA contributes to myelin synthesis and is critically needed for the development, growth and maintenance of the cerebral cortex. Low levels have been correlated with memory loss and changes in mood.

Attenuates stress response.

Release of the steroid hormones epinephrine, norepinephrine and cortisol from the adrenals occurs in response to stress and is the body's way of restoring balance. Repeated stressful events can result in damage to brain functions when adaptive mechanisms are not properly supported. Several nutritional substances in NeuroTone assist the body in limiting and balancing these neurochemical changes.

Phosphatidylserine: Numerous studies suggest that phosphatidylserine helps control the balance of stress hormones. It is involved in the body's response to counterbalance the excessive releases of adrenocorticotropic hormone (ACTH), adrenaline and cortisol upon stress. Phosphatidylserine also helps regulate nutrient transport into and metabolic waste products out of nerve cells.

Siberian Ginseng and Ashwagandha: These herbal adaptogens have long been used for their generalized anti-stress benefits at least partly by decreasing cortisol release during times of stress. These are supplied as standardized extracts with certified contents of important phytoactive compounds.

A powerful combination of neuronutrients for general or intensive supplementation.

NeuroTone's potent mix of neurotransmitter precursors and other selected neuroactive substances is designed to help balance and enhance cognitive functions. It is suitable for those who want to maintain healthy mental functions, as well as for individuals experiencing age-associated changes in brain and nervous system functions who may require more aggressive nutritional support. Two tablets twice daily supplies generous maintenance amounts of a comprehensive array of neuronutrients that can be taken daily as nutritional insurance. If needed, the dosage can be safely doubled for those who may benefit from higher potencies.

NeuroTone makes an excellent companion product to daily multivitamin mineral supplements such Basic Preventive, which forms an important nutritional foundation for enhancing overall health and well-being. Basic Preventive supplies major antioxidants and antioxidant precursors which also play an important role in neuroprotection. The brain and nervous system are especially vulnerable to the damaging effects of free radicals. The high polyunsaturated fatty content of the brain coupled with its large oxygen consumption makes it very susceptible to the deleterious effects of free radicals. Thus, maintaining antioxidant defenses is critically important to protecting the brain and neural tissues from oxidative damage. Nutrients such as vitamins E and C supplied by Basic Preventive boost the antioxidant protective properties of Ginkgo flavonoids and other nutrients in the NeuroTone formula.

NeuroTone now offers a way to obtain more comprehensive neuroprotection from a premium combination of nutrients - at significant savings over using individual supplements.

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